High-density lipoprotein: does it have a dark side?
نویسندگان
چکیده
منابع مشابه
High-density lipoprotein: does it have a dark side?
There are proven pleiotropic anti-atherogenic actions of high-density lipoprotein (HDL). However, in systemic inflammation, HDL can have pro-inflammatory properties that may contribute to accelerated atherosclerosis, likely mediated by a change in the structure of HDL to pro-inflammatory HDL (PiHDL). Validation of the technically challenging assay for PiHDL, and confirmation of an association o...
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High-density lipoproteins (HDLs) are appropriately recognized for their many atheroprotective functions, including reverse cholesterol transport, as well as antioxidant, anti-inflammatory, and antithrombotic effects. Furthermore, the inverse relationship between HDL cholesterol and atherosclerosis is well documented in many populations. However, there is an increasing body of evidence that ther...
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Low high-density lipoprotein (HDL) cholesterol levels are associated with an increased risk of coronary artery disease and myocardial infarction. Experimental studies have identified several potential anti-atherogenic properties of HDL, including promotion of macrophage cholesterol efflux, endothelial nitric oxide stimulation, anti-inflammatory and anti-thrombotic effects. These observations ha...
متن کاملHigh -density lipoprotein cholesterol as a predictor for diabetes mellitus
Background: Diabetes is a prevalent chronic disease around the world. To evaluate risk of diabetes comprehensively, we developed a score model for the risk prediction with HDL-C as a protective factor. Methods: We extracted physical examination data of 2728 individuals. The data contain 18 demographic and clinical variables. To identify the statistical significant feature variables, the backwa...
متن کاملDoes Raising High-Density Lipoprotein Matter?
The well-documented capacity of alcohol consumption to increase levels of high-density lipoprotein (HDL) cholesterol1 has generated attempts to assess the extent to which this effect might contribute to the reduced incidence of coronary heart disease (CHD) that has been observed in moderate consumers of alcohol.2 Several reports based on multiple regression models in observational cohort studie...
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ژورنال
عنوان ژورنال: Arthritis Research & Therapy
سال: 2008
ISSN: 1478-6354
DOI: 10.1186/ar2527